UNITED STATES	OMB APPROVAL OMB Number: 3235-0080 Expires: March 31, 2018 Estimated average burden hours per response: 1.7
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 25
NOTIFICATION OF REMOVAL FROM LISTING AND/OR REGISTRATION UNDER SECTION 12(b) OF THE SECURITIES EXCHANGE ACT OF 1934.
Commission File Number	001-36591
Issuer: OTONOMY, INC. Exchange: Nasdaq Stock Market LLC (Exact name of Issuer as specified in its charter, and name of Exchange where security is listed and/or registered) Address: 6275 Nancy Ridge Drive Suite 100 San Diego CALIFORNIA 92121 Telephone number: 858-242-5200 (Address, including zip code, and telephone number, including area code, of Issuer's principal executive offices) Common Stock (Description of class of securities)
Please place an X in the box to designate the rule provision relied upon to strike the class of securities from listing and registration:
17 CFR 240.12d2-2(a)(1) 17 CFR 240.12d2-2(a)(2) 17 CFR 240.12d2-2(a)(3) 17 CFR 240.12d2-2(a)(4) Pursuant to 17 CFR 240.12d2-2(b), the Exchange has complied with its rules to strike the class of securities from listing and/or withdraw registration on the Exchange. 1 Pursuant to 17 CFR 240.12d2-2(c), the Issuer has complied with its rules of the Exchange and the requirements of 17 CFR 240.12d-2(c) governing the voluntary withdrawal of the class of securities from listing and registration on the Exchange.
Pursuant to the requirements fo the Securities Exchange Act of 1934, Nasdaq Stock Market LLC certifies that it has reasonable grounds to believe that it meets all of the requirements for filing the Form 25 and has caused this notification to be signed on its behalf by the undersigned duly authorized person.
2022-12-29 By Aravind Menon Hearings Advisor Date Name Title
1 Form 25 and attached Notice will be considered compliance with the provisions of 17 CFR 240.19d-1 as applicable. See General Instructions.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

Delisting Determination, The Nasdaq Stock Market, LLC,
December 29, 2022,  Otonomy, Inc.
The Nasdaq Stock Market LLC (the Exchange) has determined
to remove from listing the common stock of Otonomy, Inc.
(the Company), effective at the opening of the trading
session on January 9, 2023.
Based on review of information provided by the Company,
Nasdaq Staff determined that the Company no longer
qualified for listing on the Exchange pursuant to
Listing Rule 5450(a)(1). The Company was notified of the
Staff determination on November 14, 2022. On November 19,
2022, the Company exercised its right to appeal the Staff
determination to the Listing Qualifications Hearings
Panel (Panel) pursuant to Rule 5815.  On December 21, 2022,
a day before the hearing, the Company informed the Panel that
it was formally withdrawing its appeal. The Company securities
were suspended on December 23, 2022.  The Staff determination
to delist the Company securities became final on December 23, 2022.